I used differin which is like retin a but newer/better, but you can't put those things very close to your eyes or they can cause eye dryness /irritation. Ever since I started using Tretinoin, my face stings when I apply any moisturtizer or makeup to my skin Even in areas that I don;t apply Tretinoin (like my eyes). Retin-A Safety Can Retin-A applied to the skin, not the eyes, cause any trouble? Obviously we know that Accutane and systemic vitamin A can cause dry eye issues. never use tretinoin, retin a- my worst nightmare veryworried82 I've been reading alot of websites, doctors advice, books on dermatology about how Retin A can improve not only your acne but your overall skin. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Walker on tretinoin under eyes: Should not be used close to your eyes. Often, they are too concentrated or the preservatives in them will irritate your eyes. Consult with your ophthalmologist about a safe eye ointment that will help your problem. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. FWIW, I used Retin-A for twenty years and never had issues with dry eyes. I can't see how the two could be related. Given that the problem arises when you wear contacts and goes away with glasses, I can't quite understand how you would think the Retin-A is the issue? You just started using Retin-A (tretinoin) to treat your acne. Now your skin is so dry, it almost looks worse than the acne itself. Unfortunately, dry, peeling, and flaky skin are pretty much par for the course when using any topical retinoid like Retin-A. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Placik on can you use tretinoin around eyes: only FDA approved for ACNE! I know of no off label use for wrinkles! Hope this is helpful! Dr z. Use of other skin products while using Retin-A (tretinoin cream) may cause more irritation. Talk with your doctor before you use other drugs or products on your skin. You may use make-up unless your doctor has told you not to.